Seven-transmembrane receptors
نویسندگان
چکیده
منابع مشابه
Seven-transmembrane receptors.
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
متن کاملQuantifying ligand bias at seven-transmembrane receptors.
Seven transmembrane receptors (7TMRs), commonly referred to as G protein-coupled receptors, form a large part of the "druggable" genome. 7TMRs can signal through parallel pathways simultaneously, such as through heterotrimeric G proteins from different families, or, as more recently appreciated, through the multifunctional adapters, β-arrestins. Biased agonists, which signal with different effi...
متن کاملSeven transmembrane receptors: something old, something new.
Receptors for hormones, neurotransmitters, drugs, sensory stimuli and many other agents represent the gateway to cellular metabolism and activity. They regulate virtually all physiological processes in mammals. Yet as recently as 40 years ago their very existence was still in question. One class of receptors, those coupled to G proteins (also known as GPCRs or seven transmembrane receptors) com...
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A Magnificent Time With the ''Magnificent Seven'' Transmembrane Spanning Receptors Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000061771.61280.B8 2003;92:342-344 Circ Res. http://circres.ahajou...
متن کاملSeven-transmembrane proteins as odorant and chemosensory receptors.
The olfactory systems of various species solve the challenging problem of general molecular recognition in widely differing ways. Despite this variety, the molecular receptors are invariably G protein-coupled seven-transmembrane proteins, and are encoded by the largest gene families known to exist in a given animal genome. Receptor gene families have been identified in vertebrates and two inver...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2015
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.26.17